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KMID : 0545120200300121854
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Journal of Microbiology and Biotechnology
2020 Volume.30 No. 12 p.1854 ~ p.1861
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Anti-Biofilm Activity of Cell-Free Supernatant of Saccharomyces cerevisiae against Staphylococcus aureus
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Kim Yeon-Jin
Yu Hwan-Hee
Park Yeong-Jin
Lee Na-Kyoung
Paik Hyun-Dong
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Abstract
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Staphylococcus aureus is one of the most common microorganisms and causes foodborne diseases. In particular, biofilm-forming S. aureus is more resistant to antimicrobial agents and sanitizing treatments than planktonic cells. Therefore, this study aimed to investigate the anti-biofilm effects of cell-free supernatant (CFS) of Saccharomyces cerevisiae isolated from cucumber jangajji compared to grapefruit seed extract (GSE). CFS and GSE inhibited and degraded S. aureus biofilms. The adhesion ability, auto-aggregation, and exopolysaccharide production of CFS-treated S. aureus, compared to those of the control, were significantly decreased. Moreover, biofilm-related gene expression was altered upon CFS treatment. Scanning electron microscopy images confirmed that CFS exerted anti-biofilm effects against S. aureus. Therefore, these results suggest that S. cerevisiae CFS has anti-biofilm potential against S. aureus strains.
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KEYWORD
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Anti-biofilm, Saccharomyces cerevisiae, cell-free supernatant, grapefruit seed extract, Staphylococcus aureus
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